Nik Stevenson runs an experiment for his Master’s thesis about Splenic Marginal Zone Lymphoma (SMZL)/Mature B-cell lymphoma in Allwine Hall at University of Nebraska at Omaha in Omaha, Nebraska, Friday, August 3, 2018.

Dreams, Failures and Breakthroughs

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UNO students make advances in cancer research, discover their career passions along the way.

Jacob Robinson’s dream of being a major league pitcher didn’t pan out. Something better did: He teamed up with fellow University of Nebraska at Omaha biology graduate student Nik Stevenson and together, this past year, made a breakthrough in cancer research — one that could make a major impact in the lives of people around the world who are fighting a rare type of lymphoma. And along the way, the two say, they discovered passions that could make a major impact in their own lives and careers.

They credit the supportive culture at UNO.

Says Robinson: “People here, especially the science faculty, are so willing to help students that I really felt like my education here was great. Because I was willing to put in the effort, people were always willing to provide opportunities for me to go as far as I wanted to go.”

Says Stevenson: “You can fail 10, 20, 100 times, and the faculty here will help you succeed. It’s an environment where you feel confident that even if you fail, you’re ultimately going to succeed, and that’s pretty important to help you flourish.”

The cancer they’re studying is called splenic marginal zone lymphoma, or SMZL. It’s a type of white blood cell cancer that hasn’t been studied a lot because it’s so rare. SMZL cases have an overall survival prognosis after diagnosis of eight to 11 years, so it’s a rather slow-progressing cancer.

But anywhere from 10% to 15% of those cases progress to a much more aggressive form in which the overall survival prognosis drops to three to five years. Their research has shown promise in predicting how aggressive a person’s cancer will be based on specific genetic markers, a breakthrough that could lead to a way to more easily diagnose this cancer.

Stevenson did the “wet bench” side of their research — the hands-on work with the cancer cells themselves. Robinson did the big-data side, studying the genetic profiles of patients with SMZL and looking for patterns for this specific blood cancer vs. other similar lymphomas.

“It’s not a terribly lethal (cancer), unless it transforms,” Robinson says. “What my research did is, I found a grouping of markers that is pretty highly predictive for the basis of diagnosis for this SMZL patient.

“Instead of having to go through a bunch of different tests, ideally you would be able to just have this panel of genetic markers from a biopsy, and you’d say yes or no, this is the lymphoma that they’re afflicted with.”

If patients have the slow-growing type, they wouldn’t have their lives disrupted as much with frequent biopsies, along with the waiting around for results, which can be scary. It also would provide more accurate diagnosis and information on the outcome of the disease’s progression.

Says Stevenson: “It would allow them to pretty much have a better quality of life for the time being.”

People here, especially the science faculty, are so willing to help students that I really felt like my education here was great. Because I was willing to put in the effort, people were always willing to provide opportunities for me to go as far as I wanted to go.

- Jacob Robinson
Nik Stevenson, left, and Jacob Robinson, right, credit UNO's supportive culture for their recent successes, including a breakthrough in research that will allow health care professionals to more easily diagnose a rare form of cancer.

The two conducted their research in Allwine Hall in the lab of Christine Cutucache, Ph.D., a rock star professor who holds the Dr. George Haddix Community Chair in Science at UNO. They call her “Dr. C.”

Dr. C, they say, gave amazing guidance and support (and coffee and doughnuts and a box overflowing with healthy snacks, which sits in the corner of the lab’s small conference room).

She served as the liaison between them and physicians and other medical professionals at the University of Nebraska Medical Center as they tried to determine the real-world usefulness of their research.

“It’s been sort of the perfect mix to have UNO as a home base but still be able to access a world-renowned med center right down the street,” Robinson says.

UNO, they say, helped them make major breakthroughs in their own lives, too.

Back in high school at Omaha North, Robinson says, he was mainly just interested in baseball, not school work. He struggled in chemistry. His dad connected him with a friend who was a retired UNO chemistry professor, James Wood, who became his tutor.

“He basically showed me how cool chemistry could be,” Robinson says.

That ignited his love for learning. (It also helped, Robinson says, smiling, that he fell in love with a great student his senior year — a young woman who is now his wife.)

At a UNO chemistry department awards night a few years back, Dr. Wood was given an envelope with a name inside. He was asked to open it and announce the chemistry student who’d be named the latest recipient of the James K. and Kathleen Wood Scholarship.

Dr. Wood didn’t know who it’d be.

It was Robinson, then a UNO junior.

Stevenson’s original dream for his career – to be a brain surgeon — also didn’t pan out.

He was a military brat, he says, born in Germany. He lived in Texas and South Dakota. He was only 8 years old and his family was living in Papillion, Nebraska, when his young mother was diagnosed with stage 4 breast cancer.

“It was everywhere when they first saw it,” he says. “It just socks you in the gut when you find out something like that.”

The cancer eventually spread to her brain, and she had brain surgery. Stevenson spent a lot of time in the hospital with her until she died when he was 12. He’d wanted to go to medical school, he says, but not getting in his first try made him reflect on that path, and he realized it wasn’t actually his main interest or career aim.

“That was a blessing in disguise because, through a little reflection, I realized I didn’t want to do that,” Stevenson says.

He met with Dr. C a year before applying to UNO and came to the university for his master’s degree because of the opportunity to join her lab.

Dr. C also runs a community outreach program called NE STEM 4U in which UNO students work to inspire middle school students in the community to consider careers in STEM fields down the road. (STEM is an acronym for science, technology, engineering and mathematics.)

Stevenson loves to coach soccer, too.

“Developing them as people, not just as athletes but just as people who can contribute to society, is a big thing I enjoy,” he says.

Dr. C noticed Stevenson’s strengths as a mentor and connected him to NE STEM 4U. He loved it.

He was its graduate adviser this past year and recently accepted a full-time job at UNO, where he will be doing science education research, continuing his role in the NE STEM 4U program and leading professional development opportunities for undergraduates and others.

“Developing people to excel in science so that one day they may pave the way for great development in the cancer research realm or in a plethora of other STEM fields,” Stevenson says, “is really my passion and my goal.”

He hopes to keep coaching soccer on the side.

This August, Robinson will start pharmacy school at the University of North Carolina-Chapel Hill.

Stevenson thinks he’ll stay in Nebraska.

“My fiancée is a farm girl from southeast Nebraska,” he says, “so I think we’re going to end up calling somewhere around Nebraska home.”

Stevenson smiles.

“Nebraska is pretty good.”

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